GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs2294008 | 1 | rs2976394 | chr8:143763622 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.18 | 7.05E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2976396 | chr8:143764001 | PSCA | chr8:143761875-143764142:+ | -0.41 | -5.07 | 1.14E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2976398 | chr8:143764879 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5 | 1.55E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2978982 | chr8:143763490 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.08 | 1.1E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs4660306 | 1 | rs2993259 | chr1:46001550 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.25 | 1.98E-11 | Homocysteine levels |
| UCEC | cis | rs30187 | 1 | rs30187 | chr5:96124330 | ERAP1 | chr5:96096515-96149837:- | -0.44 | -5.32 | 3.7E-7 | Ankylosing spondylitis |
| UCEC | cis | rs30187 | 1 | rs30378 | chr5:96121994 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.59 | 1.03E-7 | Ankylosing spondylitis |
| UCEC | cis | rs30187 | 1 | rs30379 | chr5:96122260 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.59 | 1.03E-7 | Ankylosing spondylitis |
| UCEC | cis | rs30187 | 1 | rs30380 | chr5:96122281 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.59 | 1.03E-7 | Ankylosing spondylitis |
| UCEC | cis | rs10461617 | 1 | rs3099459 | chr5:56137170 | C5orf35 | chr5:56205103-56213010:+ | 0.62 | 6.79 | 2.38E-10 | Type 2 diabetes |
| UCEC | cis | rs3204270 | 1 | rs3204270 | chr17:79682051 | ARL16 | chr17:79648234-79650954:- | -0.77 | -4.95 | 1.99E-6 | Dental caries |
| UCEC | cis | rs10461617 | 1 | rs33322 | chr5:56175226 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.47 | 1.28E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs33325 | chr5:56142547 | C5orf35 | chr5:56205103-56213010:+ | 0.61 | 6.85 | 1.7E-10 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs33326 | chr5:56142601 | C5orf35 | chr5:56205103-56213010:+ | 0.62 | 6.79 | 2.38E-10 | Type 2 diabetes |
| UCEC | cis | rs1577917 | 1 | rs34106666 | chr6:86676258 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.37 | 2.92E-7 | Response to antipsychotic treatment |